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Mitochondrial Antigen Antibody Screening (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies that may indicate an autoimmune response targeting mitochondrial proteins, often linked to conditions like autoimmune hepatitis or other inflammatory disorders.

Quick summary

["This test helps identify potential autoimmune conditions affecting your liver or other organs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49781-8
Short code
Mitochondria M2 Ab Ser-aCnc
Synonyms
Mitochondria M2 Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, abdominal pain, or unexplained liver enzyme elevations, or if you have a family history of autoimmune liver diseases.

What to Expect During the Test

A blood sample will be drawn from a vein in your arm. You may feel a slight pinch, but it usually takes only a few minutes. No special preparation is needed.

Common Conditions It May Help Diagnose

This screening test can help detect conditions such as autoimmune hepatitis, where your immune system mistakenly attacks healthy cells in your liver, or other mitochondrial-related autoimmune disorders.

What the Results Mean

Positive results suggest a possible autoimmune response, prompting further evaluation with additional tests or a specialist consultation. Negative results do not rule out other conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mitochondrial Antibody Test

Frequently asked questions

What does a positive result mean?
A positive result suggests you may have an autoimmune response against mitochondrial proteins, which could be linked to conditions like autoimmune hepatitis or other inflammatory disorders. Further testing and evaluation by a specialist are usually recommended to determine the exact cause and next steps.
What if my results are negative?
A negative result means your blood sample did not detect the specific mitochondrial antibodies tested. However, it does not rule out other autoimmune or inflammatory conditions. Your healthcare provider may recommend additional tests or monitoring based on your symptoms and medical history.
How often should I get this test?
The frequency of this test depends on your symptoms, medical history, and ongoing treatment. Your healthcare provider will determine the best schedule based on your individual needs, often during follow-up visits or if symptoms persist or worsen.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy