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Mitochondrial Antibody Profile (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies that may indicate an autoimmune condition targeting your body’s mitochondria, which are essential for energy production in cells.

Quick summary

["This screening helps identify possible autoimmune disorders affecting mitochondrial function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51794-6
Short code
Mitochondria M2 Ab Titr Ser IF
Synonyms
Mitochondria M2 Ab Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, muscle weakness, or unexplained organ dysfunction, or if you have a family history of autoimmune diseases. It can also be part of a broader evaluation for conditions like autoimmune hepatitis, diabetes, or thyroid disorders.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from your arm. The test is usually done in a lab setting and results are ready within a few days to a week.

What the Results Mean

Positive results suggest a higher likelihood of mitochondrial antibodies, which may warrant further testing or evaluation by a specialist. Negative results mean no detectable antibodies were found in this sample, but they don’t rule out other possible causes of your symptoms.

Common Conditions Linked to Positive Results

Positive findings may be associated with autoimmune diseases like autoimmune hepatitis, diabetes (type 1 or 2), thyroid disorders, or other systemic autoimmune conditions. Consult your doctor to discuss next steps, as additional testing or monitoring may be needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mitochondrial Antibody Screen

Frequently asked questions

What Does This Test Measure?
This test measures the presence of antibodies directed against mitochondrial proteins. These antibodies are part of an autoimmune response where the immune system mistakenly attacks healthy cells, including those in mitochondria, which are crucial for energy production in cells.
How Might This Affect My Health?
If antibodies are found, it may indicate an autoimmune process affecting organs or tissues, potentially leading to symptoms like fatigue, muscle weakness, or organ dysfunction. Early diagnosis can help manage symptoms and prevent complications.
Will This Test Replace Other Diagnostic Tests?
This screening test is often used as part of a broader evaluation. If results are positive, further testing (such as specific mitochondrial antibody subtypes or other blood tests) may be recommended to confirm a diagnosis and guide treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy