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Mitochondrial Antibody Screen (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against mitochondrial proteins, often used to help diagnose autoimmune conditions affecting the liver, kidneys, or other organs.

Quick summary

["This screening helps identify potential autoimmune diseases linked to mitochondrial antibodies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14251-3
Short code
Mitochondria M2 IgG Ser-aCnc
Synonyms
Mitochondria M2 IgG Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like fatigue, joint pain, liver issues, or unexplained organ dysfunction. It’s also used in cases where other autoimmune conditions (like lupus or scleroderma) are suspected but not confirmed by other tests.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The test is quick and typically done at a lab or clinic.

What the Test Results Mean

Results are qualitative (positive or negative) and not tied to specific numeric ranges. A positive result suggests the presence of mitochondrial antibodies, which may indicate an autoimmune condition requiring further evaluation.

Common Conditions Linked to Positive Results

Positive results are often seen in conditions like **mixed connective tissue disease**, **lupus**, or **autoimmune hepatitis**, though other autoimmune disorders may also be associated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mitochondrial Antibody Screen

Frequently asked questions

What does a positive result mean for my health?
A positive result means your blood contains antibodies against mitochondrial proteins. This may suggest an autoimmune condition, but it doesn’t confirm a diagnosis alone. Your doctor will likely order additional tests to explore possible causes and guide treatment options.
Can I fast before this test?
No fasting is required for this blood test. However, always follow your doctor’s instructions for any other tests or medications you’re taking.
How long will it take to get my results?
Results are typically available within a few days to a week, depending on lab processing times. Your doctor will discuss the findings with you during a follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy