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Mitochondrial Antibody Profile (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies that may indicate an autoimmune condition targeting your body’s mitochondria, which are essential for energy production in cells.

Quick summary

["This screening helps identify potential autoimmune disorders affecting mitochondrial function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63284-4
Short code
Mitochondria M5 Ab Ser Ql IF
Synonyms
Mitochondria M5 Ab Ser Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies (autoantibodies) that target mitochondrial proteins. These antibodies can be part of conditions like autoimmune hepatitis, autoimmune pancreatitis, or other systemic autoimmune diseases. Results are qualitative (positive or negative) and may not provide exact levels of these antibodies.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained liver issues, chronic fatigue, muscle weakness, or digestive problems that could be linked to mitochondrial dysfunction.

Sample Collection and Preparation

A blood sample is typically drawn from a vein in your arm. The test uses serum (liquid part of blood after clotting) to detect antibodies. No special preparation is needed, but fasting may be advised depending on other tests ordered with it.

What the Results Mean

A positive result means your blood contains antibodies against mitochondria, which may suggest an autoimmune condition. A negative result means no detectable antibodies were found in this test. Follow-up testing or further evaluation by a specialist may be needed to determine the cause of your symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Mitochondrial Antibody Screen

Frequently asked questions

What Are Common Symptoms to Watch For?
Symptoms like fatigue, muscle weakness, digestive issues (e.g., nausea, diarrhea), or unexplained weight loss could be linked to mitochondrial dysfunction. However, symptoms vary widely and may not directly correlate with test results.
How Often Should I Get This Test?
This screening test is usually done once, but your doctor may recommend repeat testing if symptoms persist or if further evaluation is needed. Follow-up depends on your overall health and clinical findings.
Can This Test Be Done at Home?
No, this test requires a blood sample collected in a clinical setting by a healthcare professional. Home testing kits are not available for this specific antibody screen.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy