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Spot Plate Mitogen-Induced Lymphocyte Proliferation Test (Blood)

Published: August 9, 2026Updated: August 16, 2026

This test measures how your immune system’s white blood cells respond to stimulation, which can help assess immune function.

Quick summary

["This test helps evaluate your body’s ability to mount an immune response to infection or disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74280-9
Short code
Mitogen IGNF.spot count Bld
Synonyms
Mitogen IGNF.spot count Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test involves collecting a small sample of whole blood and exposing it to specific mitogens (substances that stimulate immune cells). It measures how quickly and strongly your lymphocytes (a type of white blood cell) grow in response, which reflects their activity level.

Why It Might Be Ordered

Doctors may order this test to check for immune system disorders, such as HIV/AIDS, autoimmune diseases, or conditions that weaken the immune response, especially in people who have had organ transplants or are undergoing chemotherapy.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The sample is then processed to separate the white blood cells and exposed to mitogens in a controlled lab setting.

How the Results Are Interpreted

Results are compared to a baseline or reference range for healthy individuals. Lower-than-expected responses may indicate an impaired immune system, while higher-than-expected responses might suggest overactivity or inflammation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is particularly useful for monitoring immune function in patients with known or suspected immune deficiencies. It can help guide treatment decisions, such as adjusting medications or identifying the need for additional immune support.

Short name

Lymphocyte Activation Test

Frequently asked questions

What does a low lymphocyte response mean?
A low response may suggest a weakened immune system, potentially due to conditions like HIV, chemotherapy, or autoimmune diseases. Your doctor will discuss further testing or treatment options based on your overall health and symptoms.
How long does it take to get results?
Results are typically available within 3 to 5 business days, depending on lab processing times. Your healthcare provider will contact you once they are ready.
Can I eat or drink anything before this test?
No special preparation is needed for this test. However, avoid alcohol for 24 hours before your blood draw, as it may affect immune cell activity.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy