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Mass concentration of methylmalonic acid (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid, a breakdown product of certain amino acids, in your blood. It helps diagnose and monitor conditions affecting metabolism.

Quick summary

["Methylmalonic acid levels can indicate metabolic disorders or vitamin deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94458-7
Short code
MMA Ur-mCnc
Synonyms
MMA Ur-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, weight loss, or unexplained muscle weakness, or if you have a family history of metabolic disorders. It may also be used to check for conditions like vitamin B12 deficiency or inherited metabolic diseases.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours before the test if instructed by your healthcare provider. Bring any medications you’re currently taking to your appointment.

How the Test Is Performed

A blood sample is drawn from a vein in your arm by a healthcare professional. The blood is sent to a lab for analysis using a specialized method to measure methylmalonic acid concentration.

Possible Results and Their Meaning

High levels of methylmalonic acid may suggest metabolic disorders, vitamin deficiencies, or other conditions affecting how your body processes certain nutrients. Low levels are less common but may indicate underlying issues that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

MMA (Serum/Plasma)

Frequently asked questions

What does an elevated MMA level mean?
An elevated MMA level often points to a metabolic disorder, such as methylmalonic aciduria, or conditions like vitamin B12 deficiency, which can disrupt normal metabolism. Early detection is important for managing symptoms and preventing complications.
Can diet or lifestyle changes affect MMA levels?
Dietary changes alone may not significantly alter MMA levels, but managing underlying conditions (like vitamin deficiencies) or following a specialized metabolic diet, if recommended by your doctor, can help stabilize levels.
How often should I get this test?
Your doctor will determine the frequency based on your health status, symptoms, and diagnosis. Regular follow-ups may be needed if you have a known metabolic disorder or risk factors for related conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy