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Organ-specific DNA probe for tissue identification (e.g., organ of origin in biopsy samples)

Published: August 9, 2026Updated: August 16, 2026

This test uses a specialized DNA probe to help determine which organ tissue was removed during a biopsy or surgical procedure.

Quick summary

["It helps doctors identify the source of abnormal tissue for further treatment planning."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
93394-5
Short code
M. morganii DNA Bld Pos Ql NAA+probe
Synonyms
M. morganii DNA Bld Pos Ql NAA+probe
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is This Test Used For?

Organ-specific DNA testing is primarily used in cases where a biopsy is performed but the exact tissue origin is unclear. It helps confirm whether tissue was taken from the liver, lung, kidney, or another organ, especially in cases of suspected metastatic cancer or unclear primary tumors.

How Is the Sample Collected?

A small sample of tissue (biopsy) is collected during a medical procedure. The lab processes this sample to extract DNA, which is then analyzed using the specialized probe to identify organ-specific genetic markers.

What Are Common Uses in Clinical Practice?

This test is often used in oncology to determine the origin of cancerous tissue when initial diagnostic methods are inconclusive. It may also assist in guiding treatment decisions, such as choosing targeted therapies based on tissue type.

How Does This Test Differ From Other Diagnostic Tests?

Unlike general DNA sequencing or immunohistochemistry, this test focuses specifically on detecting DNA fragments from known organ tissues. It provides a rapid and precise way to identify tissue origin without extensive laboratory workup.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical in complex cases where the location of cancer or abnormal tissue is uncertain. Accurate identification of tissue origin can influence treatment options, such as choosing surgery, radiation, or targeted therapies, and may help avoid unnecessary procedures or delays in care.

Frequently asked questions

Why might my doctor request this test?
Your doctor may recommend this test if you’ve had a biopsy but are unsure which organ tissue was removed, especially if you have symptoms or test results suggesting cancer or another condition affecting multiple organs.
What should I expect during or after the test?
You’ll undergo a standard biopsy procedure under local anesthesia. The sample is sent to the lab, where DNA is analyzed. Results are typically available within a few days, and your doctor will discuss them with you.
Could this test affect my treatment plan?
Yes, if the test confirms the tissue origin, it may help tailor your treatment—such as selecting therapies designed for that specific organ type—leading to more effective and personalized care.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy