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Mixed Nonspecific Serum Group Antibody and Red Blood Cell Antibody Screening

Published: August 9, 2026Updated: August 17, 2026

This test checks for antibodies in your blood that may react against red blood cells, helping identify potential blood compatibility issues or autoimmune conditions.

Quick summary

["Helps ensure safe blood transfusions and detects possible blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
13311-6
Short code
MNSS Group Ag RBC
Synonyms
MNSS Group Ag RBC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re preparing for a blood transfusion, experiencing unexplained anemia, or showing signs of autoimmune diseases that affect red blood cells. It’s also used during pregnancy to check for Rh incompatibility or before certain surgeries.

What to Expect Before the Test

You’ll typically have a simple blood draw from a vein in your arm. No special preparation is needed, but inform your provider about any medications or recent illnesses.

What the Test Results Mean

Positive results may indicate the presence of antibodies that could react with red blood cells, requiring further testing (like confirmation) or additional evaluation by a specialist.

Common Conditions Monitored

This test helps diagnose or rule out conditions such as hemolytic anemia, autoimmune hemolytic anemia, or blood type mismatches during pregnancy or transfusions.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This screening is crucial for preventing complications during blood transfusions, such as severe reactions, and helps manage autoimmune disorders that may cause red blood cell destruction. Early detection allows for timely treatment to support your health.

Short name

ABO/Rh Group Antibody Screen

Frequently asked questions

What does a positive antibody screen mean?
A positive result means your blood contains antibodies that may attack red blood cells. This doesn’t always mean a problem yet, but it warrants further testing to determine if these antibodies are causing harm or if they’re harmless variants.
Will I need to fast before this test?
No fasting is required for this test. It’s a simple blood draw, and you can eat and drink normally.
How long will it take to get my results?
Results are usually available within 24 to 48 hours, depending on your lab’s processing time. Your provider will discuss the findings with you.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy