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Peripheral Blood Monoblast Count

Published: August 9, 2026Updated: August 17, 2026

Measures monoblasts, immature white blood cells, in peripheral blood to help evaluate certain leukemias and other blood-forming disorders.

Quick summary

["Monoblasts are not normally expected in peripheral blood, so their presence may suggest an underlying blood-forming disorder."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
34923-3
Short code
Monoblasts NFr Bld
Synonyms
Monoblasts NFr Bld
Category
liver
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302774002
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test identifies and measures monoblasts, which are immature forms of monocytes, in blood circulating outside the bone marrow. It may be used as part of the evaluation of leukemia or monitoring of a known blood disorder.

Why might I need this test?

A clinician may order this test when abnormal blood counts, symptoms such as fatigue, bruising, fever, or unusual infections suggest a possible blood-forming disorder. It can also help assess the response to treatment for leukemia.

How is the test performed?

A peripheral blood sample is collected, usually from a vein. A laboratory examines the white blood cells, often using flow cytometry or microscopy, to identify and count monoblasts.

How do I prepare for the test?

No special preparation is usually required. Follow any instructions from your healthcare professional, and tell the laboratory if you recently had a bone marrow transplant or received certain chemotherapy or immunotherapy.

Reference range

Adult: 10-40 U/LN/A

Specimen: whole-blood

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Monoblasts are normally found mainly in the bone marrow and are not usually present in meaningful numbers in peripheral blood. Their presence may indicate bone marrow involvement by acute myeloid leukemia or another myelodysplastic or myeloproliferative condition. Results must be interpreted with the blood count, symptoms, bone marrow findings, and other laboratory tests.

Short name

Monoblast Count

Frequently asked questions

What are monoblasts?
Monoblasts are immature white blood cells that normally develop into monocytes. They are produced in the bone marrow and may spill into the bloodstream in some blood disorders.
Does a monoblast result diagnose leukemia?
No. Finding monoblasts in peripheral blood can raise concern for leukemia or another marrow disorder, but diagnosis generally requires additional blood, bone marrow, and clinical findings.
Is this the same as a complete blood count?
No. A complete blood count measures the number and proportions of major blood cell types. A monoblast count specifically identifies immature monocyte-lineage cells, often as part of a broader leukemia evaluation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy