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Granulocyte Colony-Stimulating Factor (CSF) in Cerebrospinal Fluid

Published: August 9, 2026Updated: August 16, 2026

This test measures levels of a protein called granulocyte colony-stimulating factor (CSF) in your cerebrospinal fluid (CSF). CSF supports brain and spinal cord health and helps fight infections. This test may be used to diagnose or monitor conditions affecting the central nervous system.

Quick summary

["CSF protein levels can signal inflammation, infection, or other neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33252-8
Short code
Monocytes # CSF Manual
Synonyms
Monocytes # CSF Manual
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like headaches, neck stiffness, fever, or neurological problems that suggest an infection, inflammation, or other condition affecting the brain or spinal cord. It could also be part of a broader evaluation for conditions like meningitis, encephalitis, or certain tumors.

What Does the Test Involve?

A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). A needle is inserted into the lower back to draw fluid from the spinal canal. The collected fluid is then analyzed for the presence of CSF.

What to Expect Before the Test

You may be asked to empty your bladder before the procedure. Wear loose clothing, as you’ll need to lie on your side. Bring any necessary medications with you, and inform your provider about any allergies or conditions you have.

What to Expect During the Test

The procedure is usually done in a hospital or clinic setting. You’ll lie on your side with your knees bent. A numbing medicine may be applied to the lower back, and you’ll feel a slight pinch as the needle is inserted. The process takes about 10–30 minutes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Granulocyte CSF

Frequently asked questions

What does a high level of granulocyte CSF in CSF mean?
A high level of granulocyte CSF in the CSF could signal an infection (like bacterial meningitis), an inflammatory response, or other conditions affecting the central nervous system. Your provider will interpret results in the context of your symptoms and medical history.
How is this test different from other CSF tests?
Unlike standard CSF tests (e.g., white blood cell count or glucose), this test specifically measures granulocyte CSF, a protein involved in stimulating white blood cells. It’s often used alongside other CSF analyses to better diagnose conditions like infections or immune disorders.
Can I take anything to prepare for this test?
No special preparation is needed, but avoid heavy meals before the procedure. If you’re on blood thinners or have a history of bleeding disorders, inform your provider beforehand to ensure safe testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy