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Monocyte Count in Cerebrospinal Fluid (Manual Cell Differentiation)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of monocytes, a type of white blood cell, in your cerebrospinal fluid (CSF). It helps assess inflammation or infection in the brain and spinal cord.

Quick summary

["A low or high monocyte count in CSF may signal underlying neurological conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10329-1
Short code
Monocytes NFr CSF Manual
Synonyms
Monocytes NFr CSF Manual
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms like headaches, neck stiffness, fever, or neurological issues that could indicate conditions such as meningitis, encephalitis, or other inflammatory diseases in the central nervous system.

What to Expect Before the Test

No special preparation is needed. You may receive a local anesthetic to numb the area where the fluid is collected, and you might feel a slight pinch during the procedure. Avoid caffeine or alcohol before the test if instructed.

How the Test Is Performed

A healthcare provider will insert a needle into your back to collect a small amount of CSF. The sample is then examined under a microscope to count monocytes among other white blood cells.

What the Results Mean

Results are typically reported as a count of monocytes per microliter of CSF. Elevated monocyte counts may suggest chronic inflammation, infections, or autoimmune diseases affecting the CNS.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Monocyte Count

Frequently asked questions

What Does an Abnormal Result Indicate?
An elevated monocyte count in CSF can indicate chronic meningitis, subacute bacterial infections, or conditions like multiple sclerosis or sarcoidosis. A normal result does not rule out all possible causes of neurological symptoms.
How Might My Doctor Use This Test?
Your doctor may use these results to guide further testing, such as imaging studies, additional CSF analyses, or treatment adjustments based on your symptoms and overall health.
How Often Might I Need This Test?
The frequency depends on your condition. Some patients may need repeated tests to monitor progression or response to treatment, while others may only need it once for diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy