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Monocyte Fraction in Serum or Plasma (Manual Qualitative Electrophoresis)

Published: August 9, 2026Updated: August 16, 2026

This test measures the proportion of monocytes in your blood using manual electrophoresis, a method to separate blood cell types by size and charge. It helps assess immune cell distribution.

Quick summary

["This test evaluates how monocytes (a type of white blood cell) are present in your bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
66132-2
Short code
Mono+Meso NFr Fld Manual
Synonyms
Mono+Meso NFr Fld Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis separates blood components based on their movement through an electric field. Monocytes, being larger and differently charged than other white blood cells, can be visually identified and quantified in this process. This manual method is less common today but may be used for specialized screening or research purposes.

Why It Might Be Ordered

Your healthcare provider may order this test if they suspect conditions affecting white blood cell distribution, such as certain infections, immune disorders, or blood-related diseases. It can also be part of broader diagnostic evaluations for unexplained symptoms like fatigue, recurrent infections, or abnormal lab findings.

Common Uses and Considerations

While not a routine test, it may be used in specific clinical scenarios where precise monocyte fraction assessment is critical. Results are qualitative (yes/no presence) rather than quantitative, so they provide a relative comparison rather than absolute values.

What to Expect Before the Test

No special preparation is typically needed. You may draw blood from a vein in your arm, similar to other blood tests. If you have a history of bleeding disorders or clotting issues, inform your healthcare provider beforehand.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Monocyte Fraction Test

Frequently asked questions

What does a positive or abnormal result mean?
An abnormal monocyte fraction may indicate an immune response, infection, or underlying blood disorder. However, since this is a qualitative test, results alone don’t diagnose specific conditions. They’re usually interpreted alongside other clinical findings and tests.
How does this test differ from standard white blood cell counts?
Standard white blood cell counts measure total cell numbers, while this test specifically evaluates the proportion of monocytes. Both are important but serve different diagnostic purposes.
Is this test covered by insurance?
Coverage depends on medical necessity. Since this is a specialized, less common test, check with your insurance provider or healthcare team to confirm if it’s included in your benefits.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy