Mononuclear Cell Count in Cerebrospinal Fluid (Manual Count)
This test measures the number of certain white blood cells (mononuclear cells) in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. These cells can help identify infections, inflammation, or other conditions affecting the central nervous system.
["This test helps doctors assess potential neurological issues by examining white blood cells in your spinal fluid."]
Key facts at a glance
- LOINC
- 12236-6
- Short code
- Mononuc Cells NFr CSF Manual
- Synonyms
- Mononuc Cells NFr CSF Manual
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- manual-count
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have symptoms like headaches, neck stiffness, confusion, fever, or neurological problems. It’s often used to investigate conditions such as meningitis, encephalitis, or other inflammatory or infectious processes in the brain or spinal cord.
What to Expect During the Test
A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). You’ll lie on your side, and a needle is inserted into your lower back. The fluid is then sent to the lab for manual cell counting. The process usually takes a few minutes, and you may feel mild discomfort.
Preparation and Aftercare
No special preparation is needed for this test. After the procedure, you may feel tired or have a mild headache. Stay hydrated and rest for a short time. Avoid strenuous activities for a few hours. If you experience severe pain, swelling, or signs of infection (like fever or worsening headache), contact your doctor immediately.
What the Results Mean
The results show the count of mononuclear cells (like lymphocytes and monocytes) in your CSF. Elevated counts may suggest an infection, immune response, or other neurological conditions. Your doctor will interpret the results in the context of your symptoms and other tests.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
High levels of mononuclear cells in CSF can indicate conditions such as viral or bacterial meningitis, multiple sclerosis, or other inflammatory diseases of the nervous system. Low or normal counts may rule out these conditions but don’t rule out all possibilities. Your doctor will guide you on next steps based on your specific situation.
Short name
CSF Mononuclear Cells
Frequently asked questions
How long does it take to get my results?
Can I eat or drink before this test?
Is the lumbar puncture procedure painful?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy