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Mononuclear Cell Count in Fluid (Manual Count)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of mononuclear cells (white blood cells without granules) in a fluid sample, typically performed manually by a lab technician.

Quick summary

["This helps assess immune cell populations in your body’s fluids."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9305-4
Short code
Mononuc Cells NFr Fld Manual
Synonyms
Mononuc Cells NFr Fld Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to evaluate immune function, diagnose infections, or assess conditions affecting white blood cells, such as certain cancers, immune disorders, or chronic inflammation. It can also be used in research or specialized clinical settings where precise cell counts are needed.

What to Expect Before the Test

No special preparation is usually required, but you may need to fast or avoid certain medications depending on your specific test instructions. Bring any medications you’re currently taking to your appointment.

Sample Collection Process

A healthcare provider will draw a small amount of fluid (e.g., blood, lymph, or other bodily fluids) using a sterile needle or tube. The sample is then processed manually under a microscope to count mononuclear cells.

What the Results Mean

Results provide the absolute count of mononuclear cells per unit volume of fluid. Abnormal counts may indicate conditions like leukemia, lymphomas, or immune deficiencies, but interpretation depends on clinical context and other test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Manual Mononuclear Cell Count

Frequently asked questions

What causes abnormal mononuclear cell counts?
Abnormal results may be linked to infections (e.g., viral or bacterial), inflammatory conditions, or certain cancers (e.g., lymphoma). Always discuss your symptoms and test results with your doctor.
How long does it take to get results?
Results are typically available within 24–48 hours, depending on lab workload and complexity. Your healthcare provider will contact you once they’re ready to share findings.
Can I fast before this test?
No fasting is required for this test, but follow your provider’s specific instructions if you have additional tests scheduled.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy