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Mononuclear Cell Count in Blood (Absolute)

Published: August 9, 2026Updated: August 17, 2026

This test measures the number of mononuclear white blood cells (lymphocytes and monocytes) in your blood. These cells play a key role in fighting infections and maintaining immune function.

Quick summary

["This test helps assess immune health and response to infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
30443-6
Short code
Mononuc Cells NFr Gast
Synonyms
Mononuc Cells NFr Gast
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test to evaluate your immune system, diagnose or monitor conditions like infections, autoimmune diseases, or certain blood disorders. It can also help determine the effectiveness of treatments targeting the immune system.

What to Expect Before the Test

No special preparation is needed for this test. You’ll have a small needle inserted into your arm or hand to draw a blood sample. The process usually takes a few minutes, and you may feel a slight pinch or discomfort.

What the Test Results Mean

Results are typically reported as the absolute count of mononuclear cells per microliter of blood. Elevated levels may indicate conditions like chronic infections or certain cancers, while very low levels could suggest immune deficiencies or other health issues.

Common Conditions Monitored or Diagnosed

This test is often used to monitor immune function in patients with conditions like HIV/AIDS, lymphoma, or leukemia. It may also help track responses to treatments such as chemotherapy or immune-modulating therapies.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Mononuclear cell counts can provide important clues about your immune system’s status. High counts may signal overactive immune responses or infections, while low counts could indicate weakened immunity or underlying diseases affecting blood cell production.

Short name

Mononuclear Cell Count

Frequently asked questions

What does a high or low mononuclear cell count mean?
A high count might suggest chronic infections, certain cancers, or immune system overactivity. A low count could indicate immune deficiencies, bone marrow disorders, or side effects from certain medications.
How often should I get this test?
Your provider will determine the frequency based on your health needs, ongoing treatments, or symptoms. Regular monitoring may be recommended if you have a chronic condition affecting your immune system.
Can lifestyle changes affect mononuclear cell counts?
Yes, factors like stress, poor sleep, diet, and exposure to infections can influence immune cell counts. Maintaining a balanced lifestyle may support overall immune health, but this test is primarily for medical evaluation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy