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Mononuclear Cell Count in Peripheral Blood (Manual Differential)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of mononuclear cells (like lymphocytes and monocytes) in your blood, counted manually for detailed analysis.

Quick summary

["Understanding your blood cell types helps your healthcare provider diagnose conditions like infections or immune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14381-8
Short code
Mononuc Cells NFr Prt Manual
Synonyms
Mononuc Cells NFr Prt Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
CPT
86592
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to evaluate your immune system, check for infections, or monitor conditions like leukemia, lymphoma, or autoimmune diseases. It’s often used alongside other blood tests for a full picture.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. If you’re nervous, let your doctor or phlebotomist know—they can help make it more comfortable.

What the Results Mean

The manual count provides precise numbers for each type of mononuclear cell (lymphocytes, monocytes, etc.). Abnormal counts may signal infections, immune disorders, or other health issues that need further investigation.

Common Conditions Monitored

This test helps diagnose or track conditions like chronic infections, certain cancers (e.g., non-Hodgkin lymphoma), or immune deficiencies. It’s also useful in research or specialized care settings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Results may indicate whether your immune system is functioning normally. If counts are low, you might need additional tests for infections or blood disorders. If high, it could suggest chronic inflammation or other conditions. Your doctor will discuss findings and recommend next steps based on your overall health.

Short name

Mononuclear Cell Count

Frequently asked questions

How long does it take to get results?
Manual differential counts typically take longer than automated tests (often 1–3 business days). Your doctor’s office will contact you once results are ready.
Will I need to fast before this test?
No fasting is required for this blood test. Unlike some other tests, diet doesn’t affect mononuclear cell counts.
What if I have a low or high mononuclear cell count?
A low count might mean you’re at risk for infections or have an immune disorder, while a high count could signal chronic inflammation or other conditions. Your doctor will explain what these results mean for your specific situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy