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Mononuclear Cell Count in Blood

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of mononuclear white blood cells (lymphocytes and monocytes) in your blood. These cells play key roles in immune response and infection fighting.

Quick summary

["This test helps assess immune function and identify potential blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26496-0
Short code
Mononuc Cells NFr Smn
Synonyms
Mononuc Cells NFr Smn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate your immune system, check for infections, monitor conditions like leukemia, or assess blood cell counts before treatments like chemotherapy.

What Does the Result Mean?

Results can vary based on your health status. Low counts may suggest immune deficiencies or infections, while high counts could indicate chronic inflammation, certain infections, or other conditions requiring further evaluation.

What to Expect Before the Test

No special preparation is needed. You may have a simple blood draw from a vein in your arm, similar to other routine blood tests. The process is quick and usually painless.

What to Expect During the Test

You’ll likely sit or lie down while a healthcare professional inserts a small needle into your vein to collect a blood sample. The area may feel slightly sore afterward, but this is normal.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mononuclear Cells

Frequently asked questions

What causes abnormal mononuclear cell counts?
Several factors can influence these counts, including infections (like viral or bacterial), autoimmune diseases, certain medications, or underlying blood disorders. Your healthcare provider will consider your medical history and other test results to determine the cause.
How often should I get this test?
Frequency depends on your health condition and treatment plan. Your doctor may recommend this test periodically if you have ongoing health concerns, such as chronic illnesses or cancer, or if you’re undergoing treatments that affect your immune system.
Can I prepare for this test at home?
No special preparation is required, but avoid eating or drinking anything for at least 8 hours before the test if instructed by your provider, as it may affect blood test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy