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Mononuclear Cell Count in Blood (Manual Differential)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of mononuclear white blood cells (such as lymphocytes and monocytes) in your blood sample. These cells play a key role in your immune system.

Quick summary

["This test helps assess immune function and identify potential infections or inflammatory conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14384-2
Short code
Mononuc Cells NFr UrnS Manual
Synonyms
Mononuc Cells NFr UrnS Manual
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to evaluate your immune system, detect infections, or monitor conditions like leukemia, lymphoma, or autoimmune diseases. It can also help diagnose or monitor chronic illnesses like HIV or certain cancers.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re nervous, let your provider know—they can offer options like numbing cream or a different vein.

What the Test Results Mean

Results are typically reported as a count of mononuclear cells per microliter of blood. While absolute values can vary by lab, abnormal counts may suggest immune dysfunction, infection, or other health concerns. Your provider will interpret results in the context of your overall health.

Common Conditions Monitored

This test is often used alongside other blood tests to diagnose or track conditions like chronic infections, immune deficiencies, or blood disorders. For example, low counts might indicate immune suppression, while high counts could signal inflammation or infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Interpretation and Next Steps

Short name

Manual Mononuclear Cell Count

Frequently asked questions

How often will I need this test?
Your provider will determine frequency based on your symptoms, diagnosis, or treatment plan. Some patients need this test monthly, while others may only need it occasionally.
Can I eat or drink before the test?
You can eat and drink normally before the test unless instructed otherwise. Avoiding alcohol or caffeine for a few hours may help ensure accurate results.
What if my blood test results are out of range?
If your results are abnormal, your provider will discuss potential causes and next steps, such as additional tests or treatments tailored to your condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy