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Cerebrospinal Fluid (CSF) Monocyte and Macrophage Cell Count

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of immune cells (monocytes and macrophages) in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. These cells help protect against infections and inflammation in the central nervous system.

Quick summary

["Understanding your CSF immune cell count can help diagnose or monitor conditions affecting your brain and spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35025-6
Short code
Monos+Macros # CSF
Synonyms
Monos+Macros # CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like headaches, neck stiffness, fever, confusion, or neurological issues that suggest an infection, inflammation, or other condition affecting the brain or spinal cord. It’s often used alongside other tests to guide diagnosis.

What to Expect Before the Test

You’ll likely have a lumbar puncture (spinal tap) performed by a healthcare professional. This involves inserting a needle into your lower back to collect a small sample of CSF. The procedure is usually quick and may cause mild discomfort, but you’ll be given instructions to rest afterward.

What the Test Results Mean

The results focus on identifying abnormal numbers of monocytes and macrophages, which can indicate conditions like meningitis, encephalitis, multiple sclerosis, or other inflammatory or infectious processes in the central nervous system. Your results will be interpreted by a healthcare provider based on your symptoms and other test findings.

Common Conditions Monitored or Diagnosed

This test helps diagnose or monitor conditions such as viral or bacterial meningitis, encephalitis, subarachnoid hemorrhage, Guillain-Barré syndrome, or certain types of brain tumors. Elevated counts may also suggest chronic inflammatory diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Mononuclear Cells (Qualitative Count)

Frequently asked questions

What does a high or low CSF monocyte/macrophage count indicate?
A high count may signal an active infection (like meningitis), autoimmune inflammation, or other neurological conditions causing immune cell activation in the CSF. A low count could suggest a non-inflammatory condition, though this depends on clinical context.
How long does it take to get results from this test?
Results are typically available within a few days to a week, depending on lab processing times and your healthcare provider’s workflow. Your provider will contact you once they have the findings.
Is this test painful?
The procedure itself is generally mild discomfort, but most people describe it as similar to a mild needle prick. You’ll be given instructions to rest and may experience temporary soreness or mild back pain afterward.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy