Monocyte and Macrophage Function Screening Panel (Serum/Plasma)
This test measures key indicators related to your immune system’s ability to process and respond to infections, including levels of certain immune cells and proteins involved in inflammation and immune regulation.
["Assesses immune cell function and inflammation markers in your blood."]
Key facts at a glance
- LOINC
- 53126-9
- Short code
- Monos+Macros NFr Bld
- Synonyms
- Monos+Macros NFr Bld
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test includes measurements of monocytes (a type of white blood cell) and proteins or markers that reflect their activity and the broader function of macrophages (immune cells that engulf and destroy pathogens). Some tests may also evaluate substances involved in immune signaling or inflammation, such as cytokines or complement proteins, depending on the specific panel components. Results help identify whether your immune system is functioning normally or if there may be an overactive or underactive response.
Why It Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms of chronic infections, autoimmune diseases, or conditions affecting immune cell function. It could also be used to monitor treatment responses in patients with immune-related disorders or to investigate unexplained inflammation.
Common Conditions Monitored
Conditions that might be evaluated include chronic infections (e.g., tuberculosis, certain viral infections), autoimmune diseases (e.g., rheumatoid arthritis, lupus), or disorders affecting white blood cell production or function. It may also be used in research or specialized clinical settings to assess immune system health more broadly.
Sample Collection and Preparation
Blood is drawn from a vein in your arm, and the sample is processed into either serum (after clotting) or plasma (after centrifugation). The test may require specific preparation, such as fasting or avoiding certain medications, depending on the individual components included in your panel. Your provider will give you detailed instructions.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Frequently asked questions
Elevated or altered levels of these markers may suggest an overactive immune response (e.g., inflammation, infection), an underactive response (e.g., immunodeficiency), or an autoimmune condition where the body attacks its own tissues. Low monocyte counts or dysfunctional macrophage activity could indicate immune suppression or chronic disease. Always discuss results with your healthcare provider, as interpretation depends on your overall health and symptoms.
This test does not specifically diagnose COVID-19 or other infections. It may help assess your immune response to illness but is not a direct test for viral presence. For infection diagnosis, additional tests (e.g., PCR, antibody tests) are typically needed.
Your provider will give specific instructions, but generally, fasting may not be required for this test. If fasting is advised, avoid food and liquids (except water) for a set period before your appointment. Always follow their guidance to ensure accurate results.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy