Cerebrospinal Fluid Protein Electrophoresis (Manual Separation)

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like headaches, vision changes, numbness, weakness, or trouble with coordination. It’s also used to check for conditions such as multiple sclerosis, meningitis, tumors, or other neurological issues that can alter protein levels in CSF.

What to Expect Before the Test

You’ll likely have a lumbar puncture (spinal tap) to collect CSF. This involves lying on your side and having a small needle inserted into your lower back. The procedure is usually quick and may cause mild discomfort. No special preparation is needed, but inform your doctor about any medications you’re taking.

What the Test Results Mean

The test separates CSF proteins into bands (e.g., albumin, globulins) using manual electrophoresis. Abnormal patterns, such as high levels of immunoglobulin G (IgG) or specific band shapes, may suggest conditions like multiple sclerosis, infections, or tumors. Your results will be interpreted by a healthcare provider based on your symptoms and lab findings.

Common Conditions Monitored

This test is critical for diagnosing or monitoring conditions like multiple sclerosis (where protein bands may show oligoclonal bands), meningitis (elevated protein levels), or brain tumors (unusual protein patterns). It can also help rule out other neurological or inflammatory diseases.