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Serum Macromolecular Protein Electrophoresis (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of large proteins in your blood, such as albumin and globulins, using electrophoresis. It helps identify abnormal protein patterns that may indicate conditions like multiple myeloma, amyloidosis, or other disorders affecting blood proteins.

Quick summary

["This test helps diagnose or monitor conditions affecting large blood proteins."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53125-1
Short code
Monos+Macros NFr Mar
Synonyms
Monos+Macros NFr Mar
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis separates proteins in your serum based on size and charge. The test detects abnormal bands or shifts that may signal excess or missing proteins, which can be linked to diseases like plasma cell dyscrasias or chronic inflammation.

Why It’s Ordered

Your doctor may order this test if you have symptoms like unexplained weight loss, bone pain, or fatigue, or if lab results show unusual protein levels. It’s also used to monitor treatment progress in certain blood disorders.

Common Conditions Monitored

Abnormal results may suggest conditions like multiple myeloma (a cancer of plasma cells), amyloidosis (protein buildup in organs), or other systemic diseases affecting protein synthesis or breakdown.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The serum (liquid part of blood after clotting) is then separated and analyzed for protein patterns. No special preparation is needed, but fasting may be advised depending on your doctor’s instructions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Macromolecular Protein Electrophoresis (Serum)

Frequently asked questions

How long will I need to wait for results?
Results are usually available within 1–3 business days, depending on lab processing times. Your doctor will discuss them with you during your follow-up visit.
Can I eat or drink before this test?
No special diet is required unless instructed otherwise by your doctor. However, avoid alcohol and certain medications that may affect protein levels before testing.
What does an abnormal result mean?
An abnormal result may indicate an underlying condition affecting protein balance, such as a blood disorder or organ disease. Your doctor will interpret results in the context of your symptoms and other tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy