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Monocytes, Macrophages, and Neutrophils in Tissue (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test examines monocytes, macrophages, and neutrophils in a tissue specimen to help assess immune cell populations and inflammation. It is typically used in research or specialized pathology settings rather than routine blood testing.

Quick summary

["This is a specialized tissue-based evaluation of monocyte, macrophage, and neutrophil presence and characteristics."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53127-7
Short code
Monos+Macros NFr Tiss
Synonyms
Monos+Macros NFr Tiss
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Being Tested

The test looks at three related types of white blood cells found in tissue: monocytes (which circulate in blood and mature into macrophages), macrophages (tissue cells that engulf debris and microbes), and neutrophils (fast-responding infection-fighting cells). The "measured" value is the amount or presence of these cells in the sample.

Specimen and Method

A tissue specimen is examined, and the result is reported in a qualitative or arbitrary manner rather than as an exact numeric concentration. Because the method is not fully specified in the name, the test should be described generically as a tissue cell evaluation rather than tied to one laboratory technique.

Why It Might Be Ordered

Clinicians or researchers may request this kind of evaluation to understand immune cell infiltration in a tissue sample, such as in studies of inflammation, infection, or tissue repair. It is more common in specialized or research contexts than in routine clinical care.

How to Interpret Results

Results reflect the presence and relative amount of these cell types in the tissue, but without a defined numeric reference range, interpretation depends on the specific laboratory and clinical context. Discuss any findings with the ordering provider rather than comparing to a universal standard.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Monocyte/Macrophage/Neutrophil Tissue Evaluation

Frequently asked questions

Is this a routine blood test?
No. This appears to be a tissue-based, specialized evaluation rather than a standard blood count. Routine blood work usually measures circulating white blood cells quantitatively.
Will I get a numeric reference range?
Possibly not. Because the name indicates a qualitative or arbitrary result, a fixed numeric reference range may not apply; interpretation relies on the laboratory's report and clinical context.
What do monocytes, macrophages, and neutrophils do?
Monocytes mature into macrophages, which clear debris and microbes in tissue, while neutrophils are early responders to infection and inflammation. Together they are key parts of the body's immune defense and tissue response.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy