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Monocyte and Macrophage Protein Profile (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures proteins associated with monocytes and macrophages, immune cells that help fight infections and regulate inflammation. It may be used to assess immune function or response to certain conditions.

Quick summary

["Helps evaluate immune cell activity and inflammation in the body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35023-1
Short code
Monos+Macros # Prt
Synonyms
Monos+Macros # Prt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific proteins linked to monocytes and macrophages, which are key immune cells. These proteins can reflect the body’s immune response, including activation states and potential inflammation. Some proteins may be measured in their raw form or as ratios to other markers.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of immune dysfunction, chronic inflammation, or conditions affecting these cells, such as infections, autoimmune disorders, or certain cancers.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in a clinic or lab setting. The blood is processed to separate serum or plasma, which is then analyzed for protein markers. Avoid eating or drinking for a few hours before the test to ensure accurate results.

Common Conditions Monitored

This test may help monitor conditions like chronic infections, certain cancers (e.g., leukemia), or immune-related diseases where macrophage or monocyte activity is altered.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Monocyte/Macrophage Marker Panel

Frequently asked questions

What does a high or low level of these proteins mean?
High levels may suggest overactive immune responses, such as infections or inflammation, while low levels could indicate immune suppression or deficiencies. Your provider will interpret results in the context of your overall health and symptoms.
How often should I get this test?
The frequency depends on your medical condition and provider’s recommendations. Some patients may need it periodically to track changes over time, while others may only need it once for diagnosis or monitoring.
Can diet or medications affect this test?
Certain foods, supplements, or medications (e.g., steroids, antibiotics) may influence immune markers. Follow your provider’s instructions about fasting or avoiding specific substances before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy