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Monocyte and Macrophage Activation Profile (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures markers related to immune cell activation, specifically assessing levels of certain proteins produced by monocytes and macrophages in your blood.

Quick summary

["Helps evaluate immune system response and potential inflammation or infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32195-0
Short code
Monos+Macros Prt Ql Micro
Synonyms
Monos+Macros Prt Ql Micro
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microscopy-light
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects substances released by activated immune cells (monocytes and macrophages) in response to infections, chronic inflammation, or autoimmune conditions. These markers may include cytokines, chemokines, or other signaling proteins.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fever, fatigue, or unexplained weight loss, or if you’re suspected of having an infection, autoimmune disease, or chronic inflammatory condition.

Common Conditions Monitored

This test can help identify or monitor conditions such as infections (e.g., sepsis), autoimmune diseases (e.g., rheumatoid arthritis), or chronic inflammatory disorders (e.g., lupus).

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate serum or plasma, which is then analyzed for specific markers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated levels of these markers may indicate an active immune response, suggesting infection, inflammation, or an overactive immune system. Lower levels might suggest immune suppression or chronic disease stability. Results are interpreted in the context of your symptoms and medical history.

Short name

Monocyte/Macrophage Activation Test

Frequently asked questions

How long does it take to get results?
Results are usually available within 24 to 48 hours, depending on lab processing times. Your provider will discuss findings with you during your follow-up visit.
Can I eat or drink before this test?
No special preparation is needed, but avoid alcohol for 24 hours before testing if instructed by your provider.
What does it mean if my results are abnormal?
Abnormal results may signal an infection, autoimmune activity, or chronic inflammation. Your provider will explain what the findings mean in relation to your health and may recommend further testing or treatment adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy