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Monoclonal Protein Profile with Serum Immunofixation (M-protein screening and confirmation)

Published: August 9, 2026Updated: August 16, 2026

This test checks for abnormal proteins in your blood that may indicate conditions like multiple myeloma or other monoclonal gammopathies.

Quick summary

["Identifies unusual protein patterns that could signal serious blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
93360-6
Short code
Monotypic PC DNA index Mar FC-Rto
Synonyms
Monotypic PC DNA index Mar FC-Rto
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like unexplained fatigue, frequent infections, bone pain, or kidney problems. It’s also used to monitor known conditions affecting protein production in the blood.

How the Test Works

Blood is drawn and analyzed to detect specific proteins. The first part (serum protein electrophoresis) separates proteins by size, while the second part (immunofixation) confirms if any proteins are monoclonal (abnormal clones of antibodies).

What to Expect Before the Test

No special preparation is needed, but inform your doctor about medications or recent illnesses. Avoid vigorous exercise before the draw.

What to Expect During the Test

A small needle is used to collect blood from a vein in your arm. You may feel a brief pinch, but it’s quick and usually not painful.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal monoclonal proteins may indicate conditions like multiple myeloma (cancer of plasma cells), Waldenström macroglobulinemia, or benign monoclonal gammopathies. Early detection can guide treatment decisions.

Short name

MonoProtein Screen

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains unusual protein patterns that may need further testing, such as bone marrow biopsy, to determine the cause.
How often should I get this test?
Your doctor will determine the frequency based on your symptoms, medical history, and test results. Follow-up may include repeat tests or additional evaluations.
Can diet or medications affect this test?
Dietary changes or most over-the-counter medications typically won’t interfere. However, inform your doctor about any medications, especially those affecting blood or immune function.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy