Most Recent Nontreponemal Antibody Titer (Serum)
This test measures the level of antibodies in your blood that may indicate exposure to certain bacteria, though it does not specifically identify *Treponema pallidum* (the bacterium responsible for syphilis). It is often used as part of a broader evaluation for syphilis or other infections.
["This test helps track changes in antibody levels over time, supporting diagnosis and monitoring of certain infections."]
Key facts at a glance
- LOINC
- 75169-3
- Short code
- MOSTRECENTNONTREPONEMALTESTTITER
- Synonyms
- —
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects nonspecific antibodies (such as rheumatoid factor or other IgG/IgM antibodies) that may be present in the bloodstream due to past or current infections. These antibodies are not specific to syphilis but can signal broader immune responses.
Why It’s Ordered
Your healthcare provider may order this test if you have symptoms suggestive of an infection (e.g., rash, fever, fatigue) or if you’ve been exposed to a bacterial infection. It is sometimes used alongside treponemal tests for a more complete assessment.
How the Test Works
The test uses a blood sample to measure antibody levels against specific antigens (proteins) that are not unique to syphilis. Results are often reported as a titer, which indicates the highest dilution of blood that still reacts positively with the antigen.
What the Results Mean
A rising or falling titer over time can help determine if an infection is active, resolving, or resolved. However, interpretation depends on clinical context and comparison to prior results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
While this test does not confirm syphilis, it can help identify exposure to infections that trigger nonspecific antibody responses. It is typically used as part of a diagnostic algorithm alongside other tests (like treponemal tests) to guide treatment decisions. Results should always be reviewed by a healthcare provider in the context of your symptoms and medical history.
Short name
Nontreponemal Antibody Test
Frequently asked questions
What does a positive result mean?
How often will I need this test?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy