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Motility Count of Pancreatic Neutrophil Elastase (PNE) in Stool

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of neutrophil elastase, an enzyme released by white blood cells in the gut, to assess inflammation or infection in the pancreas or nearby tissues.

Quick summary

["Helps diagnose or monitor conditions affecting pancreatic or intestinal inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4463-6
Short code
Motility + Cnt Pnl Smn
Synonyms
Motility + Cnt Pnl Smn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like persistent abdominal pain, unexplained weight loss, or signs of chronic inflammation. It could also be used to check for conditions like pancreatitis, Crohn’s disease, or other gastrointestinal issues linked to elevated neutrophil activity.

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to collect a stool sample at home or during a clinic visit. Follow your provider’s instructions carefully to ensure accurate results.

What the Test Results Mean

Results may indicate inflammation or infection if elevated levels of neutrophil elastase are detected. However, interpretation depends on clinical context and other test results. Your provider will discuss findings with you.

Common Conditions Monitored

This test is often used to monitor conditions like pancreatitis, inflammatory bowel disease, or infections affecting the pancreas or intestines. It can help track how well treatments are working over time.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Stool Neutrophil Elastase Activity Test

Frequently asked questions

What does a high neutrophil elastase level in stool mean?
A high level may suggest active inflammation or infection in the pancreas, intestines, or nearby tissues. This could indicate conditions like severe pancreatitis, Crohn’s disease, or other gastrointestinal disorders. Your provider will consider the full clinical picture, including symptoms and other tests, to determine the cause.
What does a normal level mean?
A normal result typically means there is no significant inflammation or infection detected in the tested tissues. However, it does not rule out all possible causes of symptoms. If you have ongoing concerns, further evaluation may be needed.
How often should this test be repeated?
The frequency depends on your condition and treatment plan. Your healthcare provider will decide how often to repeat this test based on your symptoms, medical history, and response to treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy