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: Mycoplasma pneumoniae Antibody, Cerebrospinal Fluid

Published: August 9, 2026Updated: August 16, 2026

: This test looks for antibodies against the bacterium Mycoplasma pneumoniae in a sample of cerebrospinal fluid (the fluid that surrounds the brain and spinal cord), which can help evaluate whether this organism may be involved in a neurologic or meningeal process.

Quick summary

[": The test detects antibodies to Mycoplasma pneumoniae in spinal fluid and is interpreted together with symptoms, other lab tests, and imaging."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42993-6
Short code
M pneumo Ab Titr CSF
Synonyms
M pneumo Ab Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

: What This Test Measures

: The assay detects antibodies (immune proteins) that the body produces in response to Mycoplasma pneumoniae, a common respiratory bacterium that can occasionally cause infection outside the lungs, including the nervous system. Finding these antibodies in cerebrospinal fluid may support suspicion of an associated neurologic involvement.

: Why Cerebrospinal Fluid Is Tested

: Cerebrospinal fluid is collected by lumbar puncture (spinal tap). Testing this fluid rather than blood helps your care team look for signs of inflammation or infection directly within the central nervous system, alongside cell counts, protein, glucose, and other studies.

: How Results Are Interpreted

: Results for CSF antibody testing are not read in isolation. Antibody testing can be affected by antibody that has crossed from blood into spinal fluid, so clinicians compare CSF and blood findings and consider the overall picture. A positive or negative result alone does not confirm or exclude infection.

: What to Expect

: A lumbar puncture is usually performed after other considerations and with local numbing. Most people tolerate it well and recover quickly; your care team will explain preparation, risks, and aftercare. Laboratory turnaround varies by facility.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

: M. pneumoniae Ab, CSF

Frequently asked questions

: Does a positive result mean I definitely have a Mycoplasma infection in my nervous system?
: No. A positive antibody result by itself does not prove active central nervous system infection, because antibodies can enter the fluid from the blood. It is one piece of information interpreted with your symptoms and other tests.
: Will I need a spinal tap to do this test?
: Yes. Antibody testing in cerebrospinal fluid requires a sample collected by lumbar puncture. Your provider will discuss whether this procedure is appropriate and how to prepare.
: Can this test tell me how long I have had an infection?
: Not reliably on its own. Antibody tests generally indicate that the immune system has responded to the organism, but they do not precisely date the infection, so timing is estimated using your history and other results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy