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Cerebrospinal Fluid Antibody Titers to Neisseria Meningitidis (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies in your cerebrospinal fluid (CSF) that target *Neisseria meningitidis*, a bacterium that can cause serious infections like meningitis.

Quick summary

["It helps assess immune response to meningococcal bacteria in the brain’s protective fluid."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
28548-6
Short code
M pneumo Ab Titr CSF CF
Synonyms
M pneumo Ab Titr CSF CF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like severe headache, stiff neck, fever, or confusion, especially if you’ve been exposed to someone with meningococcal disease. It’s also used to monitor treatment response or evaluate suspected meningitis cases where other tests are inconclusive.

What to Expect Before the Test

A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). You may feel pressure or mild discomfort, but it’s usually quick. No special preparation is needed, though you might be asked to empty your bladder beforehand.

How the Test Works

The collected CSF is analyzed to detect antibodies specific to *Neisseria meningitidis*. If antibodies are present, it suggests your immune system has responded to the infection, though this alone doesn’t confirm active disease.

What the Results Mean

A positive result (antibodies detected) doesn’t always mean you have an active infection—it could indicate past exposure or vaccination. Negative results may prompt further testing or closer monitoring of symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Neisseria meningitidis antibody CSF titer

Frequently asked questions

Why is this test important for my health?
This test helps doctors diagnose suspected meningococcal meningitis by checking for immune system activity against the bacteria. Early detection is critical for starting appropriate antibiotics and preventing complications.
What does a positive result mean?
A positive result means your body has produced antibodies against *Neisseria meningitidis*, but it doesn’t always mean you’re currently infected. It could reflect past exposure, vaccination, or immune response. Consult your doctor for interpretation.
How often will I need this test?
This test is typically done once, usually during evaluation for meningitis or post-exposure. Your doctor will determine if repeat testing is needed based on symptoms and clinical judgment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy