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Pneumococcal Antibody Titer (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your body’s immune response to pneumococcal bacteria, which can cause serious infections like pneumonia, meningitis, or bloodstream infections.

Quick summary

["Helps assess immunity against pneumococcal bacteria after vaccination or exposure."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22425-3
Short code
M pneumo Ab Titr Ser
Synonyms
M pneumo Ab Titr Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you’ve received a pneumococcal vaccine (such as Prevnar or Pneumovax) and want to check if your immune system produced enough antibodies to protect you. It may also be used in people with weakened immune systems, chronic illnesses, or those at higher risk for pneumococcal infections.

What to Expect Before the Test

No special preparation is needed. A blood sample will be taken from a vein in your arm, similar to a routine blood draw. The process usually takes a few minutes and is generally comfortable.

What the Test Results Mean

Results indicate the level of antibodies against pneumococcal bacteria. A sufficient titer suggests adequate immunity, while lower levels may indicate insufficient protection and could prompt further evaluation or booster recommendations.

Common Reasons for Testing

This test is often used to monitor immunity in high-risk individuals, evaluate vaccine effectiveness, or diagnose immune deficiencies related to pneumococcal exposure.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Assessing Immunity and Risk

Short name

Pneumococcal Antibody Level

Frequently asked questions

A low antibody titer may mean you’re at higher risk for pneumococcal infections, especially if you have conditions like diabetes, HIV, or asplenia (lack of a spleen). It can guide decisions about whether a booster vaccine is needed or if additional preventive measures are required.
This test is not typically used for diagnosing active infections but can help confirm if your immune system is responding properly to vaccination or prior exposure.
How long will I need to wait for my results?
Results are usually available within 24 to 72 hours, depending on lab processing times. Your healthcare provider will discuss the findings with you during your follow-up visit.
Is this test covered by insurance?
Check with your insurance provider to confirm coverage, as this test may be ordered as part of a broader evaluation for immune function or vaccination monitoring. Some insurance plans may require prior authorization.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy