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Pneumococcal Antibody Titration by Serological Cross-Immunoassay (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of antibodies your body produces in response to pneumococcal bacteria, which can cause infections like pneumonia, bloodstream infections, or meningitis. It helps assess immunity after vaccination or exposure.

Quick summary

["Determines if your immune response to pneumococcal bacteria is adequate."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5254-8
Short code
M pneumo Ab Titr Ser CF
Synonyms
M pneumo Ab Titr Ser CF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Pneumococcal bacteria are common causes of serious infections, especially in people with weakened immune systems, young children, or the elderly. This test helps doctors check if your immune system has developed enough antibodies to protect you from these infections, particularly after receiving a pneumococcal vaccine.

When You Might Need This Test

Your doctor may recommend this test if you’ve had a pneumococcal vaccine but have symptoms of infection, if you’re at high risk for pneumococcal diseases (like those with chronic illnesses or immune deficiencies), or if you’re being evaluated for long-term immunity after vaccination.

How the Test Works

A small blood sample is taken from your arm and sent to a lab. The serum is tested using a method called immunoassay to measure the exact amount of antibodies specific to pneumococcal bacteria. This helps determine if your immune response is strong enough to protect you.

Sample Collection and Preparation

You’ll have a needle inserted into your vein to draw blood. The blood is then processed to separate the serum, which is sent to the lab for testing. No special preparation is needed, but avoid eating or drinking for a few hours before the test if instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Pneumococcal Antibody Level

Frequently asked questions

Your doctor may use this test to confirm if you have adequate immunity against pneumococcal bacteria, especially after vaccination. Low antibody levels may indicate a need for booster shots or further evaluation of your immune system.
This test helps monitor your immune response to pneumococcal vaccines and ensures you’re protected against serious infections. If your results are below expected levels, your doctor may recommend additional vaccinations or treatments to boost your immunity.
What does a low or high antibody level mean?
A low level of pneumococcal antibodies suggests your immune system may not be fully protecting you from infections caused by these bacteria. This could mean you need a booster vaccine or further medical evaluation. A high level generally indicates a strong immune response, meaning you’re likely well-protected.
How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab’s processing time. Your doctor will discuss the results with you during your follow-up visit.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy