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Pneumococcal Antibody Titration (Serum) – Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of antibodies your body produces in response to *Streptococcus pneumoniae* (pneumococcal) bacteria, often used to assess immunity after vaccination or infection.

Quick summary

["Helps determine if your immune system has developed protection against pneumococcal disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31202-5
Short code
M pneumo Ab Titr Ser IF
Synonyms
M pneumo Ab Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’ve had a pneumococcal vaccine (like Prevnar or Pneumovax) or if you’ve recently been diagnosed with pneumonia, meningitis, or another pneumococcal infection. It can also be used to check immunity in people at high risk of complications, such as those with weakened immune systems or chronic lung conditions.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The sample is sent to a lab where antibodies to pneumococcal bacteria are measured using an immunoassay method. Results are typically available within 2–5 business days.

What the Results Mean

Results are qualitative (yes/no) or semi-quantitative, indicating whether detectable antibodies are present. A positive result suggests your body has developed immunity, while a negative result may mean you need further vaccination or monitoring.

Common Reasons for Follow-Up

If your results are negative after vaccination, your provider may recommend additional doses or a booster. In cases of suspected infection, follow-up may involve further testing (e.g., cultures) or treatment adjustments.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Pneumococcal Antibody Level

Frequently asked questions

Is this test covered by insurance?
Most insurance plans cover pneumococcal antibody tests if ordered for medical necessity (e.g., post-vaccination monitoring, high-risk conditions). Check with your provider or insurance company to confirm coverage details.
How long does it take to get results?
Results are usually ready within 2–5 business days, depending on lab processing times. Your healthcare provider will contact you once available.
Can I fast before this test?
No fasting is required for this blood test. However, always follow your provider’s instructions for any other related tests or procedures.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy