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Pneumococcal Antibody Titration by Serological Luminescence Assay (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against *Streptococcus pneumoniae* (pneumococcus) in your blood. It helps determine immunity or exposure to this common bacterial cause of pneumonia, meningitis, and other infections.

Quick summary

["Assessing your immune response to pneumococcal bacteria for infection risk or vaccination effectiveness."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60533-7
Short code
M pneumo Ab Titr Ser LA
Synonyms
M pneumo Ab Titr Ser LA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
la
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you’ve had recent exposure to pneumococcal bacteria, if you’re at higher risk for infections (e.g., due to weakened immune system, chronic illness, or age), or if you’re planning to receive a pneumococcal vaccine. It can also help evaluate immune response after vaccination.

What to Expect Before the Test

You’ll typically have a small blood sample drawn from a vein in your arm. No special preparation is needed unless instructed otherwise. The sample is tested for antibodies that recognize pneumococcal antigens.

How the Test Results Are Interpreted

Results are reported as a **titration value** (a measure of antibody strength). Higher values suggest stronger immunity, while lower or undetectable values may indicate insufficient protection or recent infection. Your provider will discuss findings in the context of your medical history.

Common Uses and Considerations

This test is most useful for monitoring immunity in high-risk populations (e.g., children, elderly, or immunocompromised individuals) or evaluating vaccine efficacy. It’s not a routine screening test for general health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Pneumococcal Antibody Level (Serum)

Frequently asked questions

What does a low or undetectable antibody level mean?
A low or undetectable level may mean you’re at higher risk for pneumococcal infections, especially if you lack vaccination history or have a weakened immune system. Your provider may recommend additional precautions (e.g., pneumococcal vaccines, flu shots) or further testing.
Could this test detect a recent infection?
This test primarily measures long-term immunity, not acute infection. If you suspect recent pneumococcal infection, your provider may order additional tests (e.g., blood cultures, imaging) to confirm diagnosis.
How long does it take to get results?
Results are usually available within **1–3 business days**, depending on lab processing times. Follow-up with your healthcare provider to discuss findings and next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy