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Pneumococcal Nucleic Acid Detection in Blood by Probe-Based Assay

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from *Streptococcus pneumoniae* (pneumococcus) bacteria in your blood, using a specialized molecular probe. It helps identify if you may have an infection caused by this bacteria, even before symptoms appear.

Quick summary

["Detects pneumococcal DNA quickly to guide urgent treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49104-3
Short code
M pneumo DNA Bld NAA+probe-aCnc
Synonyms
M pneumo DNA Bld NAA+probe-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test analyzes a sample of your blood for genetic fragments from *Streptococcus pneumoniae* (pneumococcus). These fragments are detected using a highly sensitive molecular probe that binds specifically to the bacteria’s DNA. This method is highly accurate for identifying pneumococcal infection, even in early stages.

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have signs of pneumonia, sepsis, or other serious infections where pneumococcus is a suspected cause. It can also be used in high-risk groups (e.g., elderly, immunocompromised) to monitor for potential infections.

How the Test Works

The blood sample is processed to extract DNA. The molecular probe targets a unique sequence in pneumococcal DNA, allowing the test to detect its presence with high sensitivity. Results are typically available within hours, providing rapid confirmation or exclusion of infection.

Sample Collection and Preparation

A small blood sample is drawn from a vein, usually in your arm. The sample is processed immediately or stored under specific conditions to preserve DNA integrity before testing. No special preparation is needed beyond standard blood draw protocols.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Pneumococcal DNA in Blood Probe Test

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within **24 hours** or less, depending on laboratory processing times. Your healthcare provider will discuss the results with you during your follow-up visit.
What does a positive result mean?
A positive result indicates the presence of *Streptococcus pneumoniae* DNA in your blood, strongly suggesting a pneumococcal infection. This may require immediate medical evaluation and treatment with appropriate antibiotics. Follow your provider’s guidance for next steps.
Can this test be used for other infections?
No, this test is specific to *Streptococcus pneumoniae* (pneumococcus). It does not detect DNA from other bacteria, viruses, or fungi. If you have symptoms of a different infection, other tests will be needed.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy