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Immunoglobulin G (IgG) in Serum by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the levels of Immunoglobulin G (IgG), the most common type of antibody in your blood, using serum collected from a blood draw.

Quick summary

["IgG helps fight infections and supports long-term immunity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17304-7
Short code
M pneumo IgG+IgM Ser-aCnc
Synonyms
M pneumo IgG+IgM Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Immunoglobulin G (IgG)?

IgG is a type of antibody produced by your immune system to protect against bacteria and viruses. It’s the most abundant antibody in your blood and plays a key role in long-term immunity, helping your body remember past infections to fight them more effectively if encountered again. Levels of IgG can vary based on your health, immune response, and certain medical conditions.

Why Might You Need This Test?

Doctors may order an IgG test to evaluate your immune system function, diagnose conditions like immunodeficiency, assess antibody levels after vaccination, or monitor chronic diseases such as lupus or rheumatoid arthritis. It can also help determine if you have enough antibodies to protect against infections, especially in people with weakened immune systems.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (the liquid part without clots) for testing. The serum is analyzed using electrophoresis, a method that separates different proteins, including antibodies, based on their size and electrical charge.

What Do the Results Mean?

Results show the concentration of IgG in your serum. While specific reference ranges vary by lab, lower than expected levels may indicate a weakened immune response, while higher levels might suggest conditions like multiple myeloma or certain autoimmune diseases. Your doctor will interpret results in the context of your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Serum Profile

Frequently asked questions

What could cause abnormal IgG levels?
Low IgG levels can be linked to primary immunodeficiency disorders, chronic liver disease, malnutrition, or certain medications that suppress the immune system. High IgG levels may be seen in chronic infections, autoimmune diseases, or conditions like monoclonal gammopathy of undetermined significance (MGUS). Always discuss any concerns with your healthcare provider.
How often should I get this test?
The frequency depends on your medical condition and treatment plan. If you have a chronic illness or are at risk for immunodeficiency, your doctor may recommend regular monitoring. If you’re vaccinated or recovering from an infection, this test may be done less often.
Can lifestyle changes affect IgG levels?
Yes, diet, stress, and overall health can influence antibody production. Eating a balanced diet rich in vitamins (like vitamin D and B12) and maintaining good hygiene may support immune function, but IgG levels are primarily determined by your body’s immune response and underlying health conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy