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Interleukin-6 (IL-6) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of interleukin-6, a protein involved in inflammation and immune response, in your blood.

Quick summary

["IL-6 helps your body respond to infections, injuries, and chronic conditions like arthritis or cancer."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58782-4
Short code
M pneumo IgM CSF IA-aCnc
Synonyms
M pneumo IgM CSF IA-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for inflammation, monitor conditions like rheumatoid arthritis, lupus, or cancer, or evaluate responses to treatments that affect immune function. It can also help diagnose or monitor infections or other inflammatory diseases.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw in a clinic or lab. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Higher than normal levels may suggest inflammation, infection, or certain diseases. Lower levels might indicate immune suppression or certain medical conditions. Your provider will interpret results in the context of your health history.

Common Conditions Monitored

IL-6 levels are often checked in people with autoimmune diseases (like rheumatoid arthritis or lupus), infections, or cancers (such as multiple myeloma). It can also help assess how well treatments are working.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IL-6 (Serum/Plasma)

Frequently asked questions

What causes IL-6 levels to be high?
High IL-6 levels can be caused by infections, autoimmune diseases (like arthritis or lupus), injuries, or certain cancers. Stress, obesity, or some medications may also influence its levels.
Can diet or lifestyle affect IL-6 levels?
Yes, diet and lifestyle can impact inflammation. Foods high in omega-3s, antioxidants, and anti-inflammatory spices (like turmeric) may help lower IL-6. Regular exercise and managing stress also play a role.
Is IL-6 testing painful?
A blood draw for IL-6 testing is generally mild discomfort, like a pinprick. Most people feel it quickly. If you’re nervous, ask your provider about numbing cream or other options.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy