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Mycoplasma pneumoniae IgG Antibodies, Serum, Qualitative Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test looks for IgG antibodies against Mycoplasma pneumoniae in a blood serum sample. IgG antibodies generally appear after infection and can help show whether you have been exposed to this bacterium.

Quick summary

["A positive IgG result usually means you have been exposed to Mycoplasma pneumoniae at some point, not necessarily that you have an active infection right now."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5257-1
Short code
M pneumo IgM Ser Ql IA
Synonyms
M pneumo IgM Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Being Tested

The test measures IgG-class antibodies that your immune system makes in response to Mycoplasma pneumoniae, a common bacterium that can cause respiratory infections such as bronchitis and "walking pneumonia." The sample tested is serum, the clear liquid part of blood.

How the Test Works

A qualitative immunoassay is used to detect whether IgG antibodies against M. pneumoniae are present. "Qualitative" means the result is typically reported in categories such as positive, negative, or equivocal rather than as a precise number.

Why Your Clinician May Order It

This test may be ordered when a Mycoplasma infection is suspected, often alongside other tests such as IgM antibodies or molecular testing. IgG testing is most useful for showing past exposure or for comparing results from two samples taken weeks apart (paired sera).

What the Result Means

A negative result suggests no detectable IgG antibodies, which may mean you have not been exposed, though it can also occur early after infection. A positive result generally indicates exposure at some time in the past or present. Because IgG can stay detectable for a long time, a single positive result cannot by itself confirm an active infection, and results should be interpreted by your clinician in the context of your symptoms and other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

M. pneumoniae IgG

Frequently asked questions

Does a positive IgG result mean I currently have a Mycoplasma infection?
Not necessarily. IgG antibodies can remain detectable long after an infection has cleared, so a positive result usually reflects exposure at some point rather than proving an active infection. Your clinician will consider your symptoms, timing, and other test results.
Can this test tell the difference between a recent and a past infection?
A single IgG test generally cannot reliably distinguish recent from past infection. Comparing IgG levels between two samples collected a few weeks apart, or combining IgG with IgM or PCR testing, can give a clearer picture.
Do I need to fast or prepare for this test?
Usually no special preparation is needed for a blood antibody test. Follow any specific instructions from your clinician or the laboratory, and tell them about medications or conditions that might affect your immune response.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy