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Serum Protein Electrophoresis (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of different protein types in your blood serum using electrophoresis, helping identify abnormalities in protein composition.

Quick summary

["Electrophoresis helps detect conditions like multiple myeloma, liver disease, or kidney problems by analyzing protein patterns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74637-0
Short code
M Protein 2 24h Ur Elph-mRate
Synonyms
M Protein 2 24h Ur Elph-mRate
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis separates blood proteins into fractions (e.g., albumin, globulins) based on size and charge. The test quantifies the concentration of each fraction, which can reveal imbalances linked to disease.

How the Test Works

A small blood sample is drawn and placed in an electric field. Proteins migrate toward opposite charges, creating bands that are analyzed to determine their relative amounts.

Common Uses

This test is often used to diagnose conditions affecting protein production, such as plasma cell disorders, liver disease, or chronic inflammation.

When You Might Need It

Your doctor may order this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if they suspect conditions like multiple myeloma, amyloidosis, or liver/kidney disease.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Serum Protein Profile

Frequently asked questions

Why might my protein electrophoresis results be abnormal?
Abnormal results could indicate conditions like multiple myeloma (where abnormal proteins like Bence Jones proteins appear), liver disease (reduced albumin), or chronic infections (elevated acute-phase globulins). Your doctor will discuss findings in relation to your symptoms and medical history.
What do the different protein bands represent?
The bands show protein groups: albumin (fastest-moving), alpha/beta globulins, and gamma globulins (slowest). Spikes or unusual patterns may signal specific disorders, but interpretation depends on clinical context.
How long does it take to get results?
Results are typically available within 24–48 hours, but timing depends on lab processing. Follow-up with your healthcare provider to discuss next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy