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24-Hour Urine Protein Electrophoresis Profile

Published: August 9, 2026Updated: August 16, 2026

This test measures the breakdown of proteins in your urine over 24 hours using electrophoresis, a method that separates different protein types. It helps identify patterns of protein loss that may signal kidney or other health conditions.

Quick summary

["This test helps detect abnormal protein patterns in urine, which can indicate kidney disease or other health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51436-4
Short code
M Protein 24h Ur Elph-mCnc
Synonyms
M Protein 24h Ur Elph-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like frequent urination, swelling, or if tests suggest kidney problems. It’s also used to monitor kidney function or diagnose conditions like multiple myeloma or other protein-related disorders.

How the Test Works

You’ll collect all your urine over 24 hours and send it to the lab. The urine is then analyzed using electrophoresis to separate proteins into bands. Each band represents different protein types, helping identify any unusual patterns.

Sample Collection

You’ll start collecting urine at a marked time (often midnight) and keep it in a container until the next day. Empty your bladder first, then collect every urine output, including during sleep. Label the container with your name and the date.

What to Expect

No special preparation is needed, but avoid certain medications or foods that might affect protein levels. Drink plenty of water to help flush your system, but don’t overdo it to avoid diluting the sample.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein patterns (e.g., high levels of light chains or monoclonal proteins) may indicate conditions like multiple myeloma, kidney disease, or other disorders affecting protein metabolism. Your provider will interpret results in context with your symptoms and other tests.

Short name

24h Urine Protein Electrophoresis

Frequently asked questions

What does a normal result mean?
A normal result typically shows balanced protein distribution in urine, with no unusual spikes or patterns. However, results depend on your health status, so discuss findings with your provider.
How often should I get this test?
Your provider will determine frequency based on your health needs—this could be once or multiple times a year if monitoring a condition like kidney disease or cancer.
Can I drink alcohol before this test?
Avoid alcohol for 24 hours before testing, as it may affect urine protein levels and interfere with results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy