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Serum Protein Electrophoresis (Qualitative)

Published: August 9, 2026Updated: August 17, 2026

This test measures the distribution of different protein types in your blood serum using gel electrophoresis, helping identify abnormalities in protein composition.

Quick summary

["This test helps diagnose conditions affecting blood proteins, such as infections, kidney disease, or inherited disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
44932-2
Short code
M Protein 2 MFr SerPl Elph
Synonyms
M Protein 2 MFr SerPl Elph
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
7.35
Ref high
7.45
Critical range
7.2 N/A – 7.6 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Electrophoresis separates blood proteins into fractions based on size and electrical charge. The test detects variations in protein bands, which can reveal conditions like multiple myeloma, liver disease, or chronic inflammation.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if they suspect conditions like kidney disease, infections, or certain cancers.

Preparation and Sample Collection

No special preparation is needed, but fasting may not be required. A blood sample is drawn from a vein, typically in your arm, and sent to the lab for analysis.

What Are Common Findings?

Abnormal patterns may show high or low levels of specific proteins, such as albumin, globulins, or immunoglobulins. For example, a spike in one fraction might indicate a disorder like monoclonal gammopathy.

Reference range

NCBI: pH 7.35-7.45N/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis (Serum)

Frequently asked questions

How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on lab processing times. Your provider will discuss findings with you during your follow-up visit.
What does each protein band represent?
Each band corresponds to a group of proteins with similar electrical charges and sizes. Common bands include albumin (fastest-moving), alpha-globulins, beta-globulins, and gamma-globulins (slowest-moving). Abnormal bands may indicate underlying health issues.
Can diet affect protein electrophoresis results?
Dietary changes are unlikely to significantly impact protein electrophoresis results, as the test measures intrinsic protein composition. However, chronic conditions like kidney disease may require dietary adjustments, which can indirectly affect protein levels.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy