Serum Protein Electrophoresis (Quantitative)
This test measures the distribution of different protein fractions in your blood serum using electrophoresis, a technique that separates proteins based on size and charge. It helps identify abnormalities in protein levels that may indicate conditions like kidney disease, liver disorders, or certain cancers.
["Electrophoresis helps doctors spot protein imbalances that could signal serious health issues."]
Key facts at a glance
- LOINC
- 59800-3
- Short code
- M Protein 2 MFr Ur Elph
- Synonyms
- M Protein 2 MFr Ur Elph
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Ref low
- 7.35
- Ref high
- 7.45
- Critical range
- 7.2 N/A – 7.6 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- electrophoresis
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have symptoms like swelling, unexplained weight loss, fatigue, or if they suspect conditions such as multiple myeloma, liver disease, or kidney problems. It’s also used to monitor treatment progress for certain diseases. Sometimes, it’s part of a routine checkup for people at higher risk of protein-related disorders.
What to Expect Before the Test
No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your doctor recommends it. Bring any medications you’re currently taking. On the day of the test, wear comfortable clothing and avoid heavy meals. Your blood will be drawn from a vein in your arm, similar to other blood tests.
What the Results Mean
Electrophoresis divides proteins into five main zones: albumin, alpha-1, alpha-2, beta, and gamma globulins. Abnormal patterns may indicate high or low levels of specific proteins, which could signal underlying health issues. Your doctor will interpret the results in the context of your symptoms and medical history.
Common Conditions Linked to Abnormal Results
High levels of gamma globulins might suggest autoimmune diseases, infections, or multiple myeloma. Low albumin could indicate liver disease, kidney problems, or malnutrition. Unexplained spikes in beta globulins may point to conditions like gout or certain cancers. Always discuss any concerns with your healthcare provider.
Reference range
NCBI: pH 7.35-7.45N/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test plays a critical role in diagnosing and managing conditions affecting protein balance in the body. It helps doctors track disease progression, guide treatment decisions, and assess the effectiveness of therapies. Early detection of protein abnormalities can lead to timely interventions and better outcomes.
Short name
Serum Protein Profile
Frequently asked questions
What does a protein electrophoresis test measure exactly?
Can I eat or drink anything before this test?
How long does it take to get results from this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy