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Urinalysis with Protein Mass Concentration Measurement (24-hour Collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein excreted in your urine over a full day. It helps assess kidney function and detect protein loss, which can signal conditions like kidney disease or other health issues.

Quick summary

["A 24-hour urine protein test helps track kidney health by measuring daily protein loss in urine."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35561-0
Short code
M Protein 2 Ur-mCnc
Synonyms
M Protein 2 Ur-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like swelling, frequent urination, or unexplained weight changes. It’s also used to monitor kidney function in people with diabetes, high blood pressure, or a history of kidney problems.

What to Expect Before the Test

You’ll need to collect all urine for 24 hours, starting and ending with your first morning urine. Store samples at room temperature and return them to your lab on the same day. Follow your provider’s instructions carefully to ensure accurate results.

How the Test Works

The test measures the total protein content in your urine by analyzing a 24-hour urine sample. This helps determine if your kidneys are filtering protein normally or if excess protein is being lost.

What the Results Mean

Higher-than-normal protein levels in urine may indicate kidney damage, inflammation, or other conditions. Your provider will interpret results in relation to your medical history and other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Protein Mass

Frequently asked questions

What causes normal protein in urine?
Some small amounts of protein in urine are normal, especially after exercise or illness. However, if protein levels are consistently high, it may signal kidney issues that need evaluation.
How often should I get this test?
Your provider will determine how often you need this test based on your health status. Regular monitoring may be recommended if you have kidney-related conditions or risk factors.
Can I take medications or eat certain foods before the test?
Avoid foods high in protein (like meat or dairy) 24 hours before testing. Some medications (e.g., NSAIDs) may also affect results, so check with your provider beforehand.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy