Serum Protein Electrophoresis (Fractionated)
This test measures the different types of proteins in your blood, separated by size and charge, using a technique called electrophoresis. It helps identify abnormalities in protein distribution that may suggest conditions like multiple myeloma, liver disease, or other disorders.
["This test helps doctors diagnose and monitor conditions affecting protein levels in your blood."]
Key facts at a glance
- LOINC
- 59801-1
- Short code
- M Protein 3 MFr Ur Elph
- Synonyms
- M Protein 3 MFr Ur Elph
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Ref low
- 7.35
- Ref high
- 7.45
- Critical range
- 7.2 N/A – 7.6 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- electrophoresis
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
Electrophoresis separates blood proteins into distinct bands based on their electrical charge and size. The test typically identifies five main protein fractions: albumin, alpha-1 globulins, alpha-2 globulins, beta globulins, and gamma globulins (including immunoglobulins). Each fraction may be further analyzed for specific markers.
Why Is This Test Done?
A fractionated protein electrophoresis may be ordered to investigate symptoms like unexplained weight loss, fatigue, swelling, or signs of infection/inflammation. It can also help diagnose conditions such as multiple myeloma, liver disease, kidney disease, or autoimmune disorders.
How Is This Test Performed?
A small blood sample is drawn from a vein, usually in your arm. The serum (liquid part of blood without clots) is then analyzed using electrophoresis, which applies an electric current to separate proteins based on their properties.
What Are Common Findings?
Abnormal patterns may include elevated or decreased levels of specific protein fractions. For example, high gamma globulin levels might suggest an immune disorder, while abnormal alpha-2 or beta globulin bands could indicate liver or kidney issues. A doctor will interpret results in the context of your symptoms and medical history.
Reference range
NCBI: pH 7.35-7.45N/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
How long does it take to get results from this test?
What does it mean if my protein electrophoresis shows unusual bands or levels?
Can I eat or drink anything before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy