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Protein Electrophoresis (Serum or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, which helps identify abnormalities in protein distribution that may indicate conditions like multiple myeloma, liver disease, or kidney problems.

Quick summary

["This test helps diagnose and monitor conditions affecting protein levels in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32629-8
Short code
M Protein MFr Spec IFE
Synonyms
M Protein MFr Spec IFE
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immunofixation
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does the Test Measure?

Protein electrophoresis separates blood proteins into fractions (such as albumin, globulins, and other proteins) based on size and charge. This helps detect unusual patterns that may signal underlying health issues.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like unexplained weight loss, fatigue, or signs of organ dysfunction (e.g., liver or kidney issues). It’s also used to monitor conditions like multiple myeloma or other blood disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma for testing. This test does not require fasting unless specified by your healthcare provider.

Common Conditions Monitored

Abnormal protein patterns can reveal conditions such as multiple myeloma (a cancer of plasma cells), liver disease (e.g., cirrhosis), kidney disease, or certain autoimmune disorders. It may also help assess protein malnutrition or fluid imbalances.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein Electrophoresis

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 24 to 48 hours, depending on your lab’s processing schedule. Your doctor will discuss the findings with you during your follow-up visit.
Can I eat or drink before this test?
No special diet is required unless instructed by your doctor. However, if you have diabetes or another condition affecting blood proteins, follow their specific guidelines.
What are the normal results?
Normal results show balanced protein fractions. Abnormal patterns (e.g., spikes in certain proteins) may require further testing or evaluation by a healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy