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Prostate-Specific Membrane Antigen (PSMA) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures levels of PSMA, a protein often produced by prostate cancer cells, to help assess prostate health or monitor treatment.

Quick summary

["PSMA levels may indicate prostate cancer presence or progression."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
79565-8
Short code
MPS I NBS comment
Synonyms
MPS I NBS comment
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is PSMA Used For?

PSMA testing is primarily used in diagnosing, staging, and monitoring prostate cancer. It may also help evaluate prostate inflammation or infection in some cases, though less commonly than PSA (prostate-specific antigen).

How Is This Test Performed?

The test involves collecting blood (serum or plasma) and analyzing it for PSMA protein through a sensitive detection technique. Results are reported in arbitrary units concentration (ucnc).

Before the Test

You may be asked to fast for a few hours before the blood draw, though this is not always required. Avoid strenuous exercise or heavy meals just before testing to ensure accurate results.

During the Test

The blood sample is processed and sent to a lab where technicians use an immunoassay to detect PSMA protein. Results are generated within a few days and shared with your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PSMA Serum/Plasma

Frequently asked questions

How long does it take to get my results?
Results are typically available within 2 to 5 business days, depending on your lab’s processing schedule. Your healthcare provider will discuss the results with you during your follow-up visit.
Can PSMA levels change over time?
Yes, PSMA levels can fluctuate depending on factors like prostate cancer activity, treatment response, or underlying health conditions. Regular monitoring may be needed if you have prostate cancer or are at higher risk.
Is this test covered by insurance?
Coverage depends on your insurance plan and medical necessity. If this test is ordered for prostate cancer diagnosis, staging, or monitoring, your insurance may cover it. Always confirm with your insurance provider or ask your doctor for a detailed explanation of costs.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy