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Fetuin-A (Alpha-2-HS-Glycoprotein) Mass Concentration in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of fetuin-A, a protein found in your blood that plays a role in regulating calcium metabolism and may influence inflammation and vascular health.

Quick summary

["Fetuin-A helps support bone health and may be checked if you have concerns about metabolic or inflammatory conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35549-5
Short code
M racemosus IgG-mCnc
Synonyms
M racemosus IgG-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms or risk factors related to metabolic disorders, such as kidney disease, diabetes, or conditions affecting calcium metabolism. It may also be used in research or specialized clinical scenarios to assess protein levels linked to vascular or bone health.

What Does This Test Measure?

Fetuin-A is a glycoprotein produced by the liver and other tissues. Low levels may be associated with certain metabolic or inflammatory conditions, while higher levels could be relevant in specific research or clinical contexts. This test specifically measures its mass concentration in your serum.

What Does a Result Mean?

Interpretation of your result depends on clinical context, including your overall health, symptoms, and other test results. Your doctor will discuss what your specific result means for you.

Common Reasons for Testing

This test may be part of a broader evaluation for conditions like chronic kidney disease, metabolic bone disease, or inflammatory states. It is not routinely screened in most general health checks.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Fetuin-A’s Role in Health

Short name

Fetuin-A Level

Frequently asked questions

How often will I need this test?
The frequency depends entirely on your healthcare provider’s recommendations. Some tests are done once, while others may be repeated based on ongoing health monitoring or treatment plans.
What are the typical reference ranges?
Reference ranges vary by lab and may not be widely standardized. Your results will be compared to ranges specific to your healthcare provider’s lab and clinical context.
Can I prepare for this test?
No special preparation is usually needed, but follow your provider’s instructions regarding diet, medications, or activity restrictions before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy