Serum or plasma concentration of total protein by nephelometry

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help diagnose or monitor certain diseases, such as multiple myeloma or severe infections.

What Does a Low or High Result Mean?

Low total protein levels might suggest malnutrition, liver disease, kidney problems, or excessive fluid loss. High levels could indicate dehydration, multiple myeloma, or certain inflammatory conditions. However, results alone don’t diagnose a specific condition—your provider will consider your full medical picture.

Common Conditions Monitored

This test is often used to monitor kidney function, especially in patients with chronic kidney disease or those on dialysis. It may also be checked in people with liver issues, severe infections, or those recovering from surgery.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (liquid part after clotting) or plasma (liquid part before clotting) for testing. No special preparation is needed, but fasting may be advised depending on your provider’s instructions.