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Mineralocorticoid Activity (Renin-to-Aldosterone Ratio) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the ratio of renin (an enzyme) to aldosterone (a hormone) in your blood. It helps assess how well your kidneys regulate blood pressure and fluid balance.

Quick summary

["This ratio can identify conditions affecting kidney function or hormone balance, such as high blood pressure or adrenal disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30868-4
Short code
MRA Renal ves
Synonyms
MRA Renal ves
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr-angio
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like high blood pressure, unexplained weight changes, or signs of kidney problems. It’s also used to evaluate conditions like primary aldosteronism or renal artery stenosis.

What to Expect Before the Test

No special preparation is needed, but you may be asked to avoid certain medications (like blood pressure drugs) for a few days before testing. Bring a list of all medications to your appointment.

How the Test Is Performed

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis to measure both renin and aldosterone levels.

What the Results Mean

The ratio helps determine if your kidneys are producing too much or too little of these hormones. High ratios may suggest conditions like hyperaldosteronism, while low ratios could indicate kidney issues or other hormonal imbalances.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Renin-Aldosterone Ratio (RAR)

Frequently asked questions

What does a high or low ratio indicate?
A high renin-to-aldosterone ratio often points to conditions like primary aldosteronism (a hormone disorder causing high blood pressure) or kidney problems that restrict blood flow. It may also signal conditions like renal artery stenosis (narrowing of the arteries to the kidneys).
What does a normal ratio suggest?
A normal ratio typically means your kidneys are functioning well to regulate blood pressure and fluid balance. However, doctors may still recommend follow-up testing if symptoms persist or if other health concerns are present.
How often should this test be repeated?
Your doctor will determine how often to repeat this test based on your symptoms, medical history, and test results. Follow-up may be needed if you have ongoing conditions like high blood pressure or kidney disease.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy