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Serum or Plasma Mass Concentration of Total Protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein status and kidney function.

Quick summary

["Total protein levels can signal kidney health or protein loss from other sources."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35946-3
Short code
MRA TA + AA
Synonyms
MRA TA + AA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr-angio
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like kidney disease, liver problems, malnutrition, or protein loss due to conditions such as burns or chronic illness. It can also help monitor treatment responses in certain cases.

What Does a Result Mean?

Higher-than-normal levels might indicate conditions like dehydration, liver disease, or inflammation. Lower-than-normal levels could suggest malnutrition, kidney disease, or excessive protein loss (e.g., from burns or kidney filtration issues). Results are interpreted in relation to your overall health and symptoms.

Common Conditions Monitored

This test is often used to monitor kidney function, detect liver disease, or evaluate protein loss in conditions like nephrotic syndrome or severe infections.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (liquid after clotting) or plasma (liquid before clotting) for testing. This test does not require fasting unless specified by your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

Total protein levels can reflect the balance between protein synthesis and loss in your body. Abnormal results may prompt further evaluation for underlying conditions affecting protein metabolism, such as liver disease, kidney dysfunction, or chronic inflammation.
How is the test performed? This test involves a simple blood draw, and results are typically available within 1–2 days, depending on lab processing times.
Will I need to prepare for this test? No special preparation is usually needed, but your provider may advise against certain medications or activities if directed.
What are the normal reference ranges? Reference ranges can vary by lab and individual health factors, so your results will be compared to your specific lab’s standards and your overall health profile.
Can I ask about my results in person? Yes, discuss your results with your healthcare provider during your follow-up visit to understand what they mean for your health.
When might I need follow-up testing? If your results are outside the expected range, your provider may recommend additional tests or monitoring to determine the cause and guide treatment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy